Figure S1-1: Depth distribution varies significantly ( \(\le\) 0.001) among the four sequencing centers considered in this study (BCM - Baylor College of Medicine, BI - Broad Institute, BGI and WUGC - Washington University Genome Center). They show an average of 82.8 \(\pm\) 67.6 for BCM, 123.0 \(\pm\) 85.6 for BGI, 86.6 \(\pm\) 79.2 for BI and 49.4 \(\pm\) 33.8 for WUGSC.
Summary for PCA analysis:
## PC1 PC2 PC3
## Standard deviation 24.20456 13.50666 13.01586
## Proportion of Variance 0.52685 0.16406 0.15235
## Cumulative Proportion 0.52685 0.69091 0.84326
Figure S1-2: Principal component analysis for the depth of the four sequencing centers considered in this study (BCM - Baylor College of Medicine, BI - Broad Institute, BGI and WUGC - Washington University Genome Center) corroborates our findings, with an explained variance of 69.0% for the first two components.
Figure S1-3: When considering the three first components in Figure Figure S1-2, we extend the accumulated explained variance to 84.3% (BCM - Baylor College of Medicine, BI - Broad Institute, BGI and WUGC - Washington University Genome Center).